Chapter 14: Heart Failure with Reduced Ejection Fraction

• Section 14.1: Pharmacological Therapy

  • 14.1.1: Cornerstone Therapies
    • Beta-blockers, ACE inhibitors/ARBs
    • Aldosterone antagonists
  • 14.1.2: Newer Therapies
    • ARNIs (Sacubitril/valsartan)
    • SGLT2 inhibitors

• Section 14.2: Device Therapy

  • 14.2.1: Cardiac Resynchronization Therapy (CRT)
    • Indications and patient selection
    • Optimizing device settings
  • 14.2.2: ICDs
    • Primary vs. secondary prevention
    • Management of shocks

• Section 14.3: Mechanical Circulatory Support

  • 14.3.1: Short-Term Support
    • IABP, Impella, and ECMO
    • Use in cardiogenic shock
  • 14.3.2: Long-Term Support
    • VADs as bridge to transplant
    • Destination therapy

• Section 14.4: Heart Transplantation

  • 14.4.1: Patient Selection
    • Eligibility criteria
    • Contraindications
  • 14.4.2: Post-Transplant Management
    • Immunosuppression regimens
    • Rejection surveillance and infection management